Raman spectroscopy for surface evaluation of titanium alloys
O.O. Frolov, 1, P.E. Timchenko, 1, E.V. Timchenko, 1, Volova L.Т., 2, Dolgushkin D.A., 2, Nikolaenko A.N., 2, Ivanov V.V., 2, Ionov A. Y., 1, Samigullin R.T.,1
1 Samara National Research University, Samara, Russia;
2 Samara State Medical University, Institute of Experimental Medicine and Biotechnology, Samara, Russia
Abstract
Improvement of metal fixators is one of the main tasks of modern reconstructive surgery. In addition to strength characteristics, more and more attention is paid to the biointegrative properties of implants, which largely determine the effectiveness of the operation, the life of the implant, and the quality of life of patients. Improvement of endoprosthesis coatings is an actual problem of traumatology and orthopedics. The surface characteristics of implants often play a decisive role in bacterial adhesion and subsequent biofilm formation on the implant. It is of interest to create coatings for implants that prevent such complications.
The aim of the work is to evaluate the surfaces of implant samples with different types of coatings using Raman spectroscopy.
We have evaluated the spectral characteristics of the surfaces of implant samples based on VT6 titanium, fabricated using selective laser sintering technology. The samples were divided into groups. The first group included samples without coatings; in the second, samples coated with calcium hydroxyapatite. The third group consisted of samples coated with calcium hydroxyapatite, which was additionally coated with an antibacterial agent. The fourth group included samples coated with a film containing chitosan. All samples were sterilized by standard methods used in medical clinics.
The differences between groups 4 and group 1 are determined by changes in the Raman intensity on the lines ~1260, ~1416, ~1665 and 1748 cm-1. The indicated Raman lines ~1260, ~1416, ~1560, ~1665, 1748 cm-1 do not appear in the group of samples 2, but the lines in the region 950 cm-1 – 1050 cm-1 corresponding to the lines of hydroxyapatite 955-961 cm-1 (PO43- (v1)) and ~432 cm-1 (PO43- (v2)).
In group 3, the Raman intensity in the region of 950-1050 cm-1 is less pronounced than in the group of samples 2, and there are also Raman lines ~1260, ~1448, ~1560, ~1665, 1748 cm-1. In group 3, a pronounced Raman line 870 cm-1 (Benzene ring of hydroxyproline) is determined.
As a result of the studies, the spectral differences between the surface of implant samples with different types of their coatings based on VT6 titanium were established using Raman spectroscopy.
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Oleg Frolov
Samara National Research University
Russia
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