Cytotoxicity of antimycotic-loaded submicron vaterite carriers under therapeutic ultrasound treatment
Authors: Roman Verkhovskii*, Ekaterina Lengert*, Anastasiia Kozlova*, Yulia Svenskaya*.
Affiliations: * Science Medical Center, Saratov State University, 83 Astrakhanskaya str., Saratov, 410012 Russia
Abstract
Nowadays, vaterite particles are promising biocompatible, biodegradable carriers for drug delivery characterized by high payload ability, and low prime cost. The efficiency of their application was shown for transdermal, intrafollicular, and intracellular delivery of a wide range of drugs including antifungal ones. The release of cargo from vaterite carriers can be externally sped up by the ultrasound treatment (US). However, the doubts related to the safety of US application for the acceleration of CaCO3 particles degradation has appeared as solid vaterite particles inside the cell can play the role of solid sonosensitizer. Thus, a thorough investigation of vaterite particle cytotoxicity under the US treatment is required. Here we evaluate the cytotoxicity and internalization efficiency of antimycotic-loaded vaterite particles by murine fibroblasts cell line with/without US treatment in comparison with the antimycotic free form.
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Roman Verkhovskii
Science Medical Center, Saratov State University
Россия
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