Magnetic drug delivery submicron systems for breast cancer treatment: from drug encapsulation to BioBrilliouin investigation
M.V. Lomova 1, P.A. Demina 1, D.V. Voronin 1,2, A.A. Abalymov 1, Y.I. Svenskaya1, N.A. Shuhunova 1, R.A. Anisimov 1, A.V. Sadovnikov 1.
1 Science Medical Center, Saratov State University, Astrakhanskaya St. 83, 410012 Saratov, Russia
2 Department of Physical and Colloid Chemistry, National University of Oil and Gas “Gubkin University”, Leninsky Prospekt 65, 119991 Moscow, Russia
Abstract
Drug delivery systems, which are actively being developed in the scientific community, imply a multitude of functions in a minimal volumes: from the capabilities of high drug loading rates to the control of drug release and the movement of carriers in vivo by external stimuli. Studies of such carriers are standard methods that allow one to assess the degree of inclusion of nanoparticles, molecules, drugs, enzymes, DNA and RNA molecules, the preservation of their activity, and the response to external influences using the example of in vitro and in vivo models. The use of methods for label-free assessment of tissue stiffness, distribution of magnetic properties inside biological objects is currently represented by the only possible method - through Brillouin scattering spectroscopy. In the proposed work, we carried out a correlation between the magnetic properties of carriers, their mobility in modal environments, the possibilities of retention and accumulation using the vital systems.
The study was supported by a grant from the Russian Science Foundation (project No.
19-73-10123).
Speaker
Maria V. Lomova
Science Medical Center, Saratov State University, Astrakhanskaya St. 83, 410012 Saratov, Russia
Россия
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