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Prolonged-release of ceftriaxone from microchamber arrays of polylactic acid

Ekaterina A. Mordovina1, Valentina O. Plastun1, Svetlana V. Raikova2, Olga A. Sindeeva3, Irina Yu. Goryacheva1 1 Saratov State University, Saratov, Russia 2 Saratov State Medical University, Saratov, Russia 3 Skolkovo Institute of Science and Technology, Moscow, Russia

Abstract

The creation of systems for the controlled delivery of drugs is a promising scientific direction in recent years since the use of such systems can significantly increase the therapeutic effect and reduce the negative impact of potent drugs on healthy tissues of the body.
Microchamber arrays (MCA) are promising systems for controlled delivery, which are thin polymer films with ordered microcontainers allowing the encapsulation of various substances. The use of MCA for medical purposes can be carried out by the introduction of MCA during surgery, as a coating for implants / stents, or through the skin in combination with various variants of poration.
The design of MCA is based on imprinting technologies and allows combining functional and adaptive components of materials in one layer. One of the most promising, biodegradable, and biocompatible materials for the manufacture of MCA is polylactic acid (PLA). Due to its hydrophobicity, PLA has effective barrier properties for the encapsulation of various hydrophilic molecules. Сhanging the PLA concentration allows you to regulate the rate of release of substances from microcontainers.
In this work, we report on the effect of PLA concentration on the release profile of ceftriaxone from MCA and the bacterial activity of MCA on Staphylococcus aureus culture.
The work was supported by a Grant of the President of the Russian Federation (МК-4273.2021.1.4).

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Ekaterina A. Mordovina
Saratov State University, Saratov, 410012
Russia

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