Time-domain near-infrared optical tomography of neonatal brain
Alexander Kalyanov, University of Zurich, Zurich, Switzerland
Jingjing Jiang, University of Zurich, Zurich, Switzerland
Aldo Di Costanzo Mata, University of Zurich, Zurich, Switzerland
Martin Wolf, University of Zurich, Zurich, Switzerland
Abstract
The neonatal brain is a vulnerable organ and lesions due to hemorrhage and/or ischemia occur frequently in preterm neonates. Happening early in life, they often lead to long-term disabilities. Despite improved survival rate (~80%), up to 25% of extremely preterms develop cerebral palsy or a low IQ, and a significant cognitive delay is present in ~12% by school age. Even though neuroprotective therapies are existing, there is no tool available to detect ischemia or hypoxia. The only way to address this problem is to image oxygenation of preterm neonates with high spatial resolution and to detect hypoxia and bleeding as early as possible.
Near-infrared optical tomography often referred as a modality, which is able to image oxygenation level of the tissue. It has a potential to resolve local hypoxic events at a bed-side and to provide clinicians with crucial information early enough for them to intervene. Here we present the recent progress in the most advanced time-domain NIROT and discuss the future of the technique.
Speaker
Alexander Kalyanov
University of Zurich
Switzerland
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