A Model for particle transport in a branched blood vessel under the influence of magnetic field
S.F. Salem1, 2, V.V. Tuchin1, 3, 4, 5
1Department of Optics and Biophotonics, Saratov State University, Saratov 410012, Russia
2Department of Physics, Faculty of Science, Benha University, Egypt
3Interdisciplinary Laboratory of Biophotonics, Tomsk State University, Tomsk 634050, Russia
4Laboratory of Molecular Imaging, Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Russia
5Institute of Precision Mechanics and Control of the Russian Academy of Sciences, Saratov 410028, Russia
Abstract
A model has been developed to study the trajectory and capturing of particles transported in a branched blood vessel under the influence of cylindrical permanent magnet is located outside the vessel. Magnetic nanoparticles, such as Superparamagnetic iron Oxide Nanoparticles (Fe3O4) are used in this theoretical study. The magnet is placed at one branched vessel to attract the magnetic particles towards targeted locations. The fluid (blood) is assumed Newtonian; its flow is incompressible, laminar. The mechanisms of magnetic nanoparticles moving in Newtonian fluid (blood) in a static magnetic field are numerically studied in this work. The dominant magnetic and drag forces are included in the model. The equations of motion for particles in the flow are governed by a combination of magnetic equations for the permanent magnet field and the Navier-Stokes equations for fluid. These equations were solved numerically using the COMSOL Multiphysics® Modeling Software.
Keywords: magnetic nanoparticles, magnetism, Targeted drug delivery, blood vessel, permanent magnet, COMSOL Multiphysics® Software.
Speaker
Samia Salem
Phd student in Saratov state University, Faculty of Physics
Russian Federation
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