Characterization of tissue elasticity with Optical Coherence Elastography: going beyond the linear paradigm
Vladimir Y. ZAITSEV1, Alexander A. SOVETSKY1, Lev A. MATVEEV1, Alexander L. MATVEYEV1, Ekaterina V. GUBARKOVA2, Anton A. PLEKHANOV2, Marina A/ SIROTKINA2 and Natalia D. GLADKOVA2
1Institute of Applied Physics of the Russian Academy of Sciences, Russia
2Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, Russia
Abstract
In this report we present recent results related to characterization of nonlinear elastic properties of biological tissues using quantitative Compression Optical Coherence Elastoraphy (C-OCE) with application of reference silicone layers as optical stress sensors. In the reduced form this approach has already proven its efficiently for estimation of the tangent Young’s modulus of nonlinear tissues for a standardized pressure. Analysis of entire stress-strain dependences opens new possibilities for diagnostics of biological tissues, which was inaccessible within the framework of conventionally used paradigm of linear elasticity.
Speaker
V.Y. Zaitsev
Institute of Applied Physics RAS
Russia
Discussion
Ask question
